Induction of donor-specific transplantation tolerance to skin and cardiac allografts using mixed chimerism in (A + B → A) in rats

Mixed allogeneic chimerism (A + B → A) was induced in rats by reconstitution of lethally irradiated LEW recipients with a mixture of T-cell depleted (TCD) syngeneic and TCD allogeneic ACI bone marrow. Thirty-seven percent of animals repopulated as stable mixed lymphopoietic chimeras, while the remainder had no detectable allogeneic chimerism. When evaluated for evidence of donor-specific transplantation tolerance, only those recipients with detectable allogeneic lymphoid chimerism exhibited acceptance of donor-specific skin and cardiac allografts. Despite transplantation over a major histocompatibility complex (MHC)- and minor-disparate barrier, animals accepted donor-specific ACI skin and primarily vascularized cardiac allografts permanently, while rejecting third party Brown Norway (BN) grafts. The tolerance induced was also donor-specific in vitro as evidenced by specific hyporeactivity to the allogeneic donor lymphoid elements, yet normal reactivity to MHC-disparate third party rat lymphoid cells. This model for mixed chimerism in the rat will be advantageous to investigate specific transplantation tolerance to primarily vascularized solid organ grafts that can be performed with relative ease in the rat, but not in the mouse, and may provide a method to study the potential existence of organ- or tissue-specific alloantigens in primarily vascularized solid organ allografts. © 1993

Electron-photon scattering mediated by localized plasmons: A quantitative analysis by eigen-response theory

We show that the scattering interaction between a high energy electron and a photon can be strongly enhanced by different types of localized plasmons in a non-trivial way. The scattering interaction is predicted by an eigen-response theory, numerically verified by finite-difference-time-domain simulation, and experimentally verified by cathodoluminescence spectroscopy. We find that the scattering interaction associated with dark plasmons can be as strong as that of bright plasmons. Such a strong interaction may offer new opportunities to improve single-plasmon detection and high-resolution characterization techniques for high quality plasmonic materials.Comment: 4 pages, 4 figures (excluding Supporting Information

Quantifying Photorealism

Computer generated imagery, or CGI, can be used to produce renders of near photographic quality, but what makes these renders considered realistic? Do there exist certain material settings or parameters that make an object more realistic than others? If so, these values can be used to produce incredibly photorealistic renders, and unrealistic parameters can be more easily identified. Prior research in this subject utilized computer algorithms analyzing roughness, color and shadow parameters compared to photographic reference, while another utilized a small sample size of non-artist background human subjects analyzing both photographs and digital renders to determine what material and visual properties quantified photorealism. This paper introduces using a large sample size of human subjects to determine which settings in 3D rendering contribute to perceived realism, using a series of controlled material parameters applied to a selection of CAD components. These material parameters include: metallicity, roughness, specular intensity, and surface detailing intensity and distribution. Preconceived notions towards assuming how realistic a surface material looks can be validated or challenged as a result of these findings. The results of these findings will provide an insight into why certain material settings are perceived as more realistic than others, and will help improve the state of 3D rendering

Longitude distribution of solar flares

Longitude distribution of solar flare

Estimates of oceanic surface wind speed and direction using orthogonal beam scatterometer measurements and comparison of recent sea scattering theories

The wind direction properties of radar backscatter from the sea were empirically modelled using a cosine Fourier series through the 4th harmonic in wind direction (referenced to upwind). A comparison with 1975 JONSWAP (Joint North Sea Wave Project) scatterometer data, at incidence angles of 40 and 65, indicates that effects to third and fourth harmonics are negligible. Another important result is that the Fourier coefficients through the second harmonic are related to wind speed by a power law expression. A technique is also proposed to estimate the wind speed and direction over the ocean from two orthogonal scattering measurements. A comparison between two different types of sea scatter theories, one type presented by the work of Wright and the other by that of Chan and Fung, was made with recent scatterometer measurements. It demonstrates that a complete scattering model must include some provisions for the anisotropic characteristics of the sea scatter, and use a sea spectrum which depends upon wind speed

Turbulent Pair Diffusion

Kinematic Simulations of turbulent pair diffusion in planar turbulence with a -5/3 energy spectrum reproduce the results of the laboratory measurements of Jullien Phys. Rev. Lett. 82, 2872 (1999), in particular the stretched exponential form of the PDF of pair separations and their correlation functions. The root mean square separation is found to be strongly dependent on initial conditions for very long stretches of times. This dependence is consistent with the topological picture of turbulent pair diffusion where pairs initially close enough travel together for long stretches of time and separate violently when they meet straining regions around hyperbolic points. A new argument based on the divergence of accelerations is given to support this picture